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International Study Group (ISG) diagnostic criteria for Behçet's syndrome

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When to use

Major criteria

Recurrent oral ulcers major or minor aphthous ulcers or herpetiform ulcers) occurring ≥ 3 times per 1 year

Minor criteria

Recurrent genital ulcers aphthous or scarring)

Eye lesions anterior or posterior uveitis, cells in the vitreous on slit lamp exam, or retinal vasculitis)

Skin lesions erythema nodosum, pseudofolliculitis, papulopustular lesions, or acneiform nodules in post-adolescent patients not on steroids)

Positive pathergy read at 24-28 hours

Calculation

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The International Study Group (ISG) diagnostic criteria for Behçet's syndrome is a clinical calculator used to diagnose Behçet's syndrome, a rare and chronic multisystem inflammatory disorder. This calculator is applicable to patients presenting with symptoms suggestive of Behçet's syndrome, such as recurrent oral and genital ulcers, eye inflammation, and skin lesions. The ISG criteria for Behçet's syndrome is clinically useful in identifying patients with this disorder, guiding treatment decisions, and facilitating research. The criteria include recurrent oral ulceration, plus at least two of the following: recurrent genital ulceration, eye lesions, skin lesions, or a positive pathergy test. There are no specific exclusion criteria for the use of the ISG diagnostic criteria for Behçet's syndrome. However, it should be noted that these criteria are not intended to replace clinical judgment and should be used in conjunction with a comprehensive clinical evaluation. Other causes of the symptoms should be ruled out before a diagnosis of Behçet's syndrome is made.

Reference

No authors listed. Criteria for diagnosis of Behçet's disease. International Study Group for Behçet's Disease. Lancet. 1990 May 5;335(8697):1078-80.

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