Hestia criteria for pulmonary embolism treatment
Hemodynamically unstable (SBP < 100 mmHg with HR > 100/need for ICU admission/by clinician judgment)
Need for thrombolysis or embolectomy
Active bleeding or high risk for bleeding (GI bleeding < 2 weeks, stroke < 4 weeks, recent surgery < 2 weeks, bleeding disorder or thrombocytopenia, uncontrolled hypertension)
> 24 hours on supplemental oxygen to maintain SaO₂ > 90%
PE during anticoagulant treatment
Severe pain needing IV pain medication > 24 hours
Medical or social reason for treatment in hospital > 24 hours
CrCl < 30 mL/min by Cockcroft-Gault
Severe liver impairment
Pregnancy
Documented history of heparin-induced thrombocytopenia
Risk of venous thromboembolism recurrence, major bleeding and mortality is low. Consider outpatient treatment.
Reference
W Zondag, I C M Mos, D Creemers-Schild et al. Outpatient treatment in patients with acute pulmonary embolism: the Hestia Study. J Thromb Haemost. 2011 Aug;9(8):1500-7.
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