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ESC diagnostic criteria for dilated cardiomyopathy in relatives

Major criteria
Unexplained decrease of LVEF ≤ 50% but > 45%
Unexplained LV end-diastolic dilatation (diameter or volume) according to nomograms (LVEDD/volume > 2 SDs + 5%)
Minor criteria
Complete LBBB, or AV block (PR > 200 ms or higher degree AV block)
Unexplained ventricular arrhythmia (> 100 ventricular premature beats per hour in 24 hours or non-sustained VT, ≥ 3 beats at a rate of ≥ 120 bpm)
Segmental wall motion abnormalities in the left ventricle in the absence of intraventricular conduction defect
Late enhancement of nonischemic origin on cardiac MRI
Evidence of nonischemic myocardial abnormalities (inflammation, necrosis, and/or fibrosis) on endomyocardial biopsy
Presence of serum organ-specific and disease-specific anti-heart antibodies by ≥ 1 autoantibody tests
Carrying the causative mutation identified in the proband
Yes
No
Diagnostic criteria are not met
Reference
Yigal M Pinto, Perry M Elliott, Eloisa Arbustini et al. Proposal for a revised definition of dilated cardiomyopathy, hypokinetic non-dilated cardiomyopathy, and its implications for clinical practice: a position statement of the ESC working group on myocardial and pericardial diseases. Eur Heart J. 2016 Jun 14;37(23):1850-8.
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