ESC diagnostic criteria for dilated cardiomyopathy in relatives
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Major criteria
Unexplained decrease of left ventricular ejection fraction ≤ 50% but > 45%
Unexplained left ventricular end-diastolic dilatation diameter or volume) according to nomograms left ventricular end-diastolic diameter/volume > 2 standard deviations + 5%)
Minor criteria
Complete left bundle branch block, or atrioventricular block PR > 200 ms or higher degree atrioventricular block)
Unexplained ventricular arrhythmia > 100 ventricular premature beats per hour in 24 hours or non-sustained ventricular tachycardia, ≥ 3 beats at a rate of ≥ 120 beats per minute)
Segmental wall motion abnormalities in the left ventricle in the absence of intraventricular conduction defect
Late enhancement of nonischemic origin on cardiac magnetic resonance imaging
Evidence of nonischemic myocardial abnormalities inflammation, necrosis, and/or fibrosis) on endomyocardial biopsy
Presence of serum organ-specific and disease-specific anti-heart antibodies by ≥ 1 autoantibody tests
Carrying the causative mutation identified in the proband
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