The Clinical Index of Stable Febrile Neutropenia (CISNE) is a risk stratification tool used in the management of adult cancer patients with chemotherapy-induced febrile neutropenia. This calculator is designed to identify low-risk patients who may be suitable for outpatient management or early hospital discharge. The CISNE score is based on seven clinical variables including burden of chronic illness, stress-induced hyperglycemia, and systolic blood pressure. It is not recommended for use in patients with severe sepsis or septic shock, or in those with rapidly progressive or life-threatening conditions.

Clinical Index of Stable Febrile Neutropenia (CISNE)

# Description:
The Clinical Index of Stable Febrile Neutropenia (CISNE) is a risk stratification tool used in the management of adult cancer patients with chemotherapy-induced febrile neutropenia. This calculator is designed to identify low-risk patients who may be suitable for outpatient management or early hospital discharge. The CISNE score is based on seven clinical variables including burden of chronic illness, stress-induced hyperglycemia, and systolic blood pressure. It is not recommended for use in patients with severe sepsis or septic shock, or in those with rapidly progressive or life-threatening conditions.
---
# Inputs:
## ECOG Performance Status
A. < 2 (+0)
B. >= 2 (+2)

## Stress-induced hyperglycemia
C. Yes (+2)
D. No (+0)

## COPD
E. Yes (+1)
F. No (+0)

## Chronic cardiovascular disease
G. Yes (+1)
H. No (+0)

## Mucositis NCI grade >= 2
I. Yes (+1)
J. No (+0)

## Monocytes
K. >= 200/mcL (+0)
L. < 200/mcL (+1)
---
# Scoring:
- If score == 0, then Risk of severe complications is 1.1%
- If score <= 2, then Risk of severe complications is 6.2%
- If score >= 3, then Risk of severe complications is  36%)

Prediction of serious complications in patients with seemingly stable febrile neutropenia: validation of the Clinical Index of Stable Febrile Neutropenia in a prospective cohort of patients from the FINITE study.