ABCD-10 Mortality Prediction Model for Stevens-Johnson Syndrome/Toxic Epidermal Necrolysis

The ABCD-10 Mortality Prediction Model for Stevens-Johnson Syndrome/Toxic Epidermal Necrolysis (SJS/TEN) is a clinical calculator used to predict the mortality risk in patients diagnosed with Stevens-Johnson Syndrome or Toxic Epidermal Necrolysis. These are severe skin reactions often triggered by medications, with TEN being more severe than SJS. The ABCD-10 model applies specifically to patients diagnosed with SJS/TEN and is used to guide clinical decision-making and patient counseling by providing an estimate of the patient's risk of mortality. The calculator uses four variables: Age (A), Bicarbonate level (B), Cancer (C), and Dialysis (D), with the '10' referring to the 10-point scale used. Each variable contributes to the total score, which correlates with the patient's mortality risk. There are no specific exclusion criteria for the use of the ABCD-10 model, but it should be noted that it may not be as accurate in patients with atypical presentations of SJS/TEN or in those with other severe concurrent illnesses that could independently affect mortality.

Reference

Megan H Noe, Misha Rosenbach, Rebecca A Hubbard et al. Development and Validation of a Risk Prediction Model for In-Hospital Mortality Among Patients With Stevens-Johnson Syndrome / Toxic Epidermal Necrolysis-ABCD-10. JAMA Dermatol. 2019 Apr 1;155(4):448-454.