Coenzyme Q10 (CoQ10) has been studied for various medical conditions, with varying levels of evidence supporting its use:
Heart failure
- CoQ10 has been investigated as an adjunctive treatment in chronic heart failure. A randomized controlled trial (Q-SYMBIO) found that long-term CoQ10 treatment was safe, improved symptoms, and reduced major adverse cardiovascular events
- However, a Cochrane review concluded that there is currently no convincing evidence to support or refute the use of CoQ10 for heart failure, and future trials are needed to confirm these findings
Hypertension
- A review found moderate-quality evidence that CoQ10 does not have a clinically significant effect on blood pressure in the long-term management of primary hypertension
Migraine prophylaxis
- CoQ10 has been recommended as a third-line choice for migraine prophylaxis by the EFNS 2009 guidelines
- A meta-analysis found that CoQ10 supplementation reduced the duration and frequency of migraine attacks, although it did not significantly reduce the intensity of headaches.
Overall, while CoQ10 shows potential benefits in certain conditions like heart failure and migraine prophylaxis, the evidence is not conclusive, and further research is needed to establish its efficacy across various medical conditions.